Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | RCC cell lines (786-O, ACHN, A704, A498) |
| Expression Pattern | up-regulated |
| Function Description | The results of the present study demonstrated that lncRNA-TUG1 was able to promote RCC cell proliferation, migration and invasion in vitro by suppressing miR-196a. Additionally, lncRNA-TUG1 achieved its biological functions by regulating the expression levels of RAC-? serine/threonine-protein kinase, mitogen-activated protein kinase and extracellular signal-regulated kinase via inhibition of miR-196a. In conclusion, the present findings proposed a novel potential therapeutic target, the lncRNA-TUG1-miR-196a axis, which may be applicable to the treatment of RCC. |
| Pubmed ID | 30387842 |
| Year | 2018 |
| Title | Long noncoding RNA TUG1 promotes renal cell carcinoma cell proliferation, migration and invasion by downregulating microRNA-196a. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |