Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | CCA tissues, cell lines (QBC939, Huh-28, HuCCT1, KMBC, CCLP-1, HCCC-9810 and RBE) |
| Expression Pattern | up-regulated |
| Function Description | up-regulation of TUG1 in both CCA tissues and cell lines. overexpression of TUG1 is linked to tumor size (p=0.005), TNM stage (p=0.013), postoperative recurrence (p=0.036) and overall survival (p=0.010) of CCA patients. TUG1 may be a rational CCA-related prognostic factor and therapeutic target. |
| Pubmed ID | 29029475 |
| Year | 2017 |
| Title | The prognostic potential and carcinogenesis of long non-coding RNA TUG1 in human cholangiocarcinoma. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |