Basic Information
LncRNA/CircRNA Name | TUG1 |
Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
Region | GRCh38_22:30969245-30979395 |
Ensemble | ENSG00000253352 |
Refseq | NR_002323 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | esophageal squamous cell carcinoma |
ICD-0-3 | NA |
Methods | qPCR, RNAi, Flow cytometry assay etc. |
Sample | ESCC tissues |
Expression Pattern | up-regulated |
Function Description | TUG1 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues, and high expression level of TUG1 was associated with family history and upper segment of esophageal cancer. Further, in vitro silencing TUG1 via siRNA inhibited the proliferation and migration of ESCC cells and blocked the progression of cell cycle. |
Pubmed ID | 25366138 |
Year | 2014 |
Title | Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma. |
External Links
Links for TUG1 | GenBank HGNC NONCODE |
Links for esophageal squamous cell carcinoma | OMIM COSMIC |