Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell migration and invasion assay etc. |
| Sample | cervical cancer tissues, cell lines (HeLa, CaSki, SiHa, and C33A) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines. Elevated TUG1 expression was correlated with larger tumor size, advanced international federation of gynecology and obstetrics (FIGO) stage, poor differentiation, and lymph node metastasis. Furthermore, knockdown of TUG1 suppressed cell proliferation with activation of apoptosis, in part by regulating the expression of Bcl-2 and caspase-3. Silencing of TUG1 inhibited cell migration and invasion via the progression of epithelial-mesenchymal transition (EMT). |
| Pubmed ID | 28088836 |
| Year | 2017 |
| Title | Upregulation of long noncoding RNA TUG1 promotes cervical cancer cell proliferation and migration. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |