Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | urothelial cancer |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | urothelial carcinoma tissues, cell lines (VM-CUB1, SW-1710, HT-1376, 5637, and BFTC-905) |
| Expression Pattern | differential expression |
| Function Description | Altered expression of individual lncRNAs was associated with overall survival, but not consistently between both patient cohorts. Interestingly, lower expression of TUG1 in a subset of UC patients with muscle-invasive tumours was significantly correlated with worse OS in both cohorts. |
| Pubmed ID | 28430799 |
| Year | 2017 |
| Title | Diagnostic and prognostic value of long noncoding RNAs as biomarkers in urothelial carcinoma |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for urothelial cancer | OMIM COSMIC |