Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | blood, osteosarcoma tissues |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues and was closely correlated with tumor size, post-operative chemotherapy, and Enneking surgical stage. Upregulation of TUG1 strongly correlated with poor prognosis and was an independent prognostic indicator for overall survival and progression-free survival. |
| Pubmed ID | 26499949 |
| Year | 2016 |
| Title | Upregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |