Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (HCT116, LoVo, RKO, SW620, and SW480) |
| Expression Pattern | up-regulated |
| Function Description | Here, we reported that TUG1 was upregulated in CRC. Further experiments revealed that TUG1 knockdown significantly inhibited cell proliferation, migration and invasion of CRC in vitro. |
| Pubmed ID | 27421138 |
| Year | 2016 |
| Title | Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |