Basic Information
| LncRNA/CircRNA Name | CASC15 |
| Synonyms | CASC15, LINC00340, lnc-SOX4-1 |
| Region | GRCh38_6:21664772-22368328 |
| Ensemble | ENSG00000272168 |
| Refseq | NR_015410 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNA-ISH etc. |
| Sample | melanoma tissues, cell lines (WP, M16, and RKTJ-CB1) |
| Expression Pattern | up-regulated |
| Function Description | In clinical specimens, CASC15 levels increased during melanoma progression and were independent predictors of disease recurrence in a cohort of 141 patients with AJCC (American Joint Committee on Cancer) stage III lymph node metastasis. Moreover, small interfering RNA (siRNA) knockdown experiments revealed that CASC15 regulates melanoma cell phenotype switching between proliferative and invasive states. |
| Pubmed ID | 26016895 |
| Year | 2015 |
| Title | The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching. |
External Links
| Links for CASC15 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |