Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, MIT |
| Sample | bladder cancer tissues, cell lines (T24 and BIU-87) |
| Expression Pattern | up-regulated |
| Function Description | The levels of TUG1 and ZEB2 were significantly increased in bladder cancer tissues and cells. Moreover, ZEB2 was verified as a direct target of miR-142 and miR-142 could specially bind to TUG1. |
| Pubmed ID | 28503069 |
| Year | 2017 |
| Title | Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1/miR-142/ZEB2 axis in bladder cancer cells |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |