Basic Information
| LncRNA/CircRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H |
| Region | GRCh38_22:30969245-30979395 |
| Ensemble | ENSG00000253352 |
| Refseq | NR_002323 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, MTT assay etc. |
| Sample | bladder cancer tissues, cell line (T24) |
| Expression Pattern | up-regulated |
| Function Description | We observed significantly increased levels of TUG1 in tumor tissue in comparison to adjacent non-tumor bladder tissue. TUG1 levels were significantly increased in metastatic tumors and were associated with shorter overall survival of MIBC patients. TUG1 silencing in vitro led to 34 % decrease in cancer cell proliferation and 23 % reduction in migration capacity of cancer cells. |
| Pubmed ID | 27460088 |
| Year | 2016 |
| Title | Overexpression of long non-coding RNA TUG1 predicts poor prognosis and promotes cancer cell proliferation and migration in high-grade muscle-invasive bladder cancer. |
External Links
| Links for TUG1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |