Basic Information
| LncRNA/CircRNA Name | TUSC7 |
| Synonyms | NA |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | cell cultures(HCT116, COLO205, HT29, SW480 and CaCO-2 cells) and the normal colon epithelial cell line NCM460 |
| Expression Pattern | down-regulated |
| Function Description | The expression of TUSC7 was decreased in CRC cells compared to the expression in the normal colon epithelial cell line NCM460. Moreover, overexpression of TUSC7 inhibited CRC cell proliferation, metastasis, invasion and EMT. These findings indicated that TUSC7 is involved in CRC development. |
| Pubmed ID | 31002365 |
| Year | 2019 |
| Title | Overexpression of lncRNA TUSC7 Reduces Cell Migration and Invasion in Colorectal Cancer |
External Links
| Links for TUSC7 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |