Basic Information
| LncRNA/CircRNA Name | TUSC7 |
| Synonyms | NA |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | Pancreatic tumor tissues, pancreatic cancer cell lines (SW1990, BxPC-3, Capan2, and Panc-1) and human pancreatic duct epithelial cell line HPDE6, HEK293T cells |
| Expression Pattern | down-regulated |
| Function Description | TUSC7 was notably decreased in tissues and cell lines of pancreatic carcinoma. Moreover, the low expression of TUSC7 was correlated with advanced clinical grades and poorer overall survival. Our findings revealed that TUSC7 repressed cell proliferation, migration, invasion, epithelial mesenchymal transition, and stemness whereas facilitated cell apoptosis of pancreatic carcinoma cells. Further investigations demonstrated that miR 371a 5p directly bound with TUSC7 and negatively regulated by TUSC7. MiR 371a 5p rescued the inhibitory effects of TUSC7 on the development of pancreatic carcinoma. We conclude that lncRNA TUSC7 suppresses pancreatic carcinoma progression by modulating miR 371a 5p expression, indicating an innovative therapeutic strategy for pancreatic carcinoma. |
| Pubmed ID | 30714151 |
| Year | 2019 |
| Title | LncRNA TUSC7 suppresses pancreatic carcinoma progression by modulating miR-371a-5p expression. |
External Links
| Links for TUSC7 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |