Basic Information
| LncRNA/CircRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma multiforme |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell line (U87), GBM tissues |
| Expression Pattern | down-regulated |
| Function Description | Low expression of TUSC7 in GBM cells and tissues resistant to TMZ.Upregulation of TUSC7 suppressed both TMZ resistance and expression of multidrug resistance protein 1 (MDR1) in U87TR cells.TUSC7 acted by directly targeting and silencing expression of miR-10a gene,and miR-10a mediated TUSC7-induced inhibition on TMZ resistance in U87TR cells. |
| Pubmed ID | 29397407 |
| Year | 2018 |
| Title | Long non-coding RNA TUSC7 inhibits temozolomide resistance by targeting miR-10a in glioblastoma. |
External Links
| Links for TUSC7 | GenBank HGNC NONCODE |
| Links for glioblastoma multiforme | OMIM COSMIC |