Basic Information
| LncRNA/CircRNA Name | TUSC8 |
| Synonyms | NA |
| Region | GRCh38_13:44400250-44405984 |
| Ensemble | ENSG00000237361 |
| Refseq | NR_104174 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, Western blotting, RIP etc. |
| Sample | Para-carcinoma tissues and CC tissues, Hela cells (CC cell line) |
| Expression Pattern | down-regulated |
| Function Description | The expressions of TUSC8 and PTEN were decreased in CC tissues, whereas miR-641 expression was increased. Inhibition of miR-641 suppressed the migration and invasion of Hela cells. In addition, TUSC8 and PTEN were upstream and downstream target molecule of miR-641, respectively. Overexpression of TUSC8 promoted PTEN expression, and suppressed the invasion and migration of Hela cells, whereas miR-641 mimic treatment changed the effects. |
| Pubmed ID | 31033083 |
| Year | 2019 |
| Title | LncRNA TUSC8 Inhibits the Invasion and Migration of Cervical Cancer Cells via miR-641/PTEN Axis |
External Links
| Links for TUSC8 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |