Basic Information
| LncRNA/CircRNA Name | LINC-UBC1 |
| Synonyms | BLACAT1, LINC00912, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Western blot, qPCR, other |
| Sample | serum samples |
| Expression Pattern | up-regulated |
| Function Description | Kaplan-Meier analysis showed that non-muscle-invasive BC (NMIBC) patients with high UBC1 expression had significantly lower recurrence-free survival (P = 0.01). Multivariate Cox analysis demonstrated that UBC1 was independently associated with tumour recurrence of NMIBC (P = 0.018). Our study suggested that lncRNAs in serum exosomes may serve as considerable diagnostic and prognostic biomarkers of BC. |
| Pubmed ID | 30467945 |
| Year | 2019 |
| Title | Evaluation of serum exosomal LncRNA-based biomarker panel for diagnosis and recurrence prediction of bladder cancer. |
External Links
| Links for LINC-UBC1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |