Basic Information
| LncRNA/CircRNA Name | UBE2CP3 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | hepatocellular carcinoma tissues, cell lines (HepG2 and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | UBE2CP3 expression was higher in HCC tissues than in para-tumor tissues and was up-regulated in tissues with high EV density. High level of UBE2CP3 and high EV density were associated with reduced overall survival time. Functionally, we found that in the co-culture systems, HCC cells overexpressing UBE2CP3 promoted HUVEC proliferation, migration and tube formation via the activation of ERK/HIF-1?/p70S6K/VEGFA signalling, increasing the level of VEGFA in HCC cell supernatant. In addition, the opposite results appeared when the expression of UBE2CP3 in HCC cells was knocked down. Consistent with these results, CAM angiogenesis assays and nude mouse tumorigenicity assays showed that UBE2CP3 expression up-regulated EV density in vivo. |
| Pubmed ID | 29866133 |
| Year | 2018 |
| Title | Long Non-Coding RNA UBE2CP3 Enhances HCC Cell Secretion of VEGFA and Promotes Angiogenesis by Activating ERK1/2/HIF-1?/VEGFA Signalling in Hepatocellular Carcinoma |
External Links
| Links for UBE2CP3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |