Basic Information
| LncRNA/CircRNA Name | UBE2R2-AS1 |
| Synonyms | NA |
| Region | GRCh38_9:33785950-33818795 |
| Ensemble | ENSG00000235481 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | tumor tissues vs non-tumor brain tissues ,glioma cell lines( U251, A-172, U87-MG, and U373) ,normal cell line HA1800 |
| Expression Pattern | down-regulated |
| Function Description | UBE2R2-AS1 was dramatically downregulated in glioma compared with normal tissue.UBE2R2-AS1 regulated glioma cell proliferation, apoptosis, and migration.UBE2R2-AS1 acted as a competing endogenous RNA (ceRNA) to target Toll-like receptor 4 (TLR4) mRNA by binding to miR-877-3p. Furthermore, lncRNA UBE2R2-AS1 suppressed glioblastoma cell growth, migration, and invasion, as well as promoting cell apoptosis by targeting miR-877-3p/TLR4 directly. |
| Pubmed ID | 31123407 |
| Year | 2019 |
| Title | Long Noncoding RNA UBE2R2-AS1 Promotes Glioma Cell Apoptosis via Targeting the miR-877-3p/TLR4 Axis |
External Links
| Links for UBE2R2-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |