Basic Information
| LncRNA/CircRNA Name | UC001kfo |
| Synonyms | ACTA2-AS1, ZXF1, uc001kfo.1 |
| Region | GRCh38_10:88932390-88940820 |
| Ensemble | ENSG00000180139 |
| Refseq | NR_125373 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RNA Sequencing etc. |
| Sample | cell line (HepG2) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA, UC001kfo,which was highly expressed in HCC tissues and could regulate the expression of a-SMA.the expression of many genes associated with cancer cell invasion and metastasis was decreased with the down-regulation of the lncRNA UC001kfo. LncRNA UC001kfo may play a role in regulating cancer cell invasion and metastasis. It was suggested that mRNAs were differentially expressed in the HepG2 cell line after the down-regulation of lncRNA-UC001kfo. Some took part in the extracellular matrix, cell adhesion, motility, growth, and localization. The genes encoding of differentially expressed mRNAs may participate in cell invasion and metastasis. |
| Pubmed ID | 28786067 |
| Year | 2017 |
| Title | Differential expression of genes in HepG2 cells caused by UC001kfo RNAi as shown by RNA-seq. |
External Links
| Links for UC001kfo | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |