Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | NA |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | ESCC tissues,cell lines (KYSE30, KYSE70, KYSE150, KYSE180, KYSE410 and EC109) |
| Expression Pattern | down-regulated |
| Function Description | CASC2 was significantly downregulated in ESCC tissues and positively correlated with overall survival time of patients with ESCC. CASC2 could exert as a tumor suppressive lncRNA in ESCC progression via regulating SOCS1. |
| Pubmed ID | 31728180 |
| Year | 2019 |
| Title | Long noncoding RNA CASC2 suppresses esophageal squamous cell carcinoma progression by?increasing SOCS1 expression |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |