Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | papillary thyroid cancer tisues, cell lines (TPC-1 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | It was demonstrated that the expression level of UCA1 was more significantly upregulated in PTC cell lines and tissues when compared with the immortal human thyroid follicular cell line and adjacent normal tissues, respectively. UCA1 knockdown significantly inhibited PTC cell viability, colony formation and the bromodomain containing 4 (BRD4) expression level in vitro, and retarded PTC tumor growth in vivo. In addition, by conducting dual luciferase reporter assays, it was confirmed that miR-204 directly binds to UCA1 and the 3'-untranslated region of BRD4. Furthermore, UCA1 competed with BRD4 for miR-204 binding. miR-204 knockdown enhanced BRD4 expression, which can be partially restored by short hairpin-UCA1. The results of the present study illustrated that UCA1 promotes PTC progression by acting as a competing endogenous RNA by sponging miR-204. |
| Pubmed ID | 30015945 |
| Year | 2018 |
| Title | Long Non-coding RNA UCA1 Promotes Papillary Thyroid Cancer Cell Proliferation via miR-204-mediated BRD4 Activation |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |