Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | non small cell lung cancer cell lines (A549) |
| Expression Pattern | up-regulated |
| Function Description | The UCA1 levels were both up-regulated in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC), as compared to non-cancerous controls. Higher levels of UCA1 pointed to a poorer overall survival in NSCLC, with the HR being 1.3. Both MTS and Cell Titer-blue assays showed an accordant inhibitory effect of UCA1 siRNAs on the cell growth. UCA1 effect on caspase-3/7 activity and apoptosis through RNA interference experiment. |
| Pubmed ID | 31938341 |
| Year | 2018 |
| Title | Clinical Implication of UCA1 in Non-Small Cell Lung Cancer and Its Effect on caspase-3/7 Activation and Apoptosis Induction in Vitro |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |