Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Western blotting, Luciferase Reporter Assay, RIP, qRT-PCR |
| Sample | CRC tissues,whole blood samples |
| Expression Pattern | up-regulated |
| Function Description | UCA1 performed a pivotal function in the tumor progression of CRC by packaging into exosomes. UCA1 affects the proliferation and apoptosis of CRC cells by functioning as a ceRNA to regulate MYO6 expression by sponging miR-143.Downregulation of UCA1 Promotes G1 Arrest and Causes Apoptosis in CRC Cells In Vitro.UCA1 Was Upregulated in CRC Tissues and Cell Lines. |
| Pubmed ID | 31955010 |
| Year | 2020 |
| Title | Circulating lncRNA UCA1 Promotes Malignancy of Colorectal Cancer via the miR-143/MYO6 Axis |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |