Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase reporter analysis, RIP, Western blot assay |
| Sample | blood sample,AML cell lines (KG-1a and THP-1, ATCC, Manassas, VA), and human bone marrow stromal cell line HS-5 (ATCC) |
| Expression Pattern | up-regulated |
| Function Description | an escalation of UCA1 expression and suppression of miR-204 expression in pediatric AML patients and cells.UCA1 downregulation repressed cell proliferation and promoted apoptosis through inactivating SIRT1 signals by upregulating miR-204 in pediatric AML. |
| Pubmed ID | 31916649 |
| Year | 2020 |
| Title | Silencing of lncRNA UCA1 Curbs Proliferation and Accelerates Apoptosis by Repressing SIRT1 Signals by Targeting miR-204 in Pediatric AML |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |