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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug	Cisplatin and temozolomide
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	glioma
ICD-0-3	NA
Methods	qRT-PCR , Western blot etc.
Sample	glioma tissues and adjacent normal brain tissues ,human astrocytes and glioma cell lines( SHG44,U251, U87 and SHG139)
Expression Pattern	up-regulated
Function Description	UCA1 was found to be highly up-regulated in glioma cells, and knock-down of UCA1 inhibited cell growth, invasion and migration, and also induced apoptosis in glioma cells.Overexpression of UCA1 promoted cell proliferation, cell invasion and migration in glioma cells.Knock-down of UCA1 suppressed the activity of Wnt/?-catenin signaling, and treatment with lithium chloride restored the inhibitory effect of UCA1 knock-down on cell invasion and migration.More importantly, the aberrant expression of UCA1 was associated with chemo-resistance to cisplatin and temozolomide in glioma cells via interacting with Wnt/?-catenin signaling.Overexpression of UCA1 promoted the in vivo tumor growth of U87 cells in the nude mice. Clinically, UCA1 was found to be up-regulated in glioma tissues and higher expression level of UCA1 was correlated with poor survival in patients with glioma.
Pubmed ID	31596734
Year	2019
Title	The Long Non-Coding RNA, Urothelial Carcinoma Associated 1, Promotes Cell Growth, Invasion, Migration, and Chemo-Resistance in Glioma Through Wnt/?-catenin Signaling Pathway

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