Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | human CRC cell line SW480 |
| Expression Pattern | NA |
| Function Description | UCA1 promotes the migration and invasion of SW480 cells without alterations in MRTF-A expression levels.UCA1 promotes MRTF-A nuclear transport by decreasing the phosphorylation of MRTF-A protein .UCA1 regulates the migration and invasion of SW480 via MRTF-A.The migration and invasive abilities of SW480 cells were positively associated with the expression of UCA1.the expression of MMP9 and MMP6 was significantly upregulated when UCA1 was overexpressed . Similarly, when UCA1 was silenced, the expression of MMP6 and MMP9 was significantly downregulated compared with the control . However, the expression of MRTF-A was markedly affected by alterations in UCA1 expression levels . |
| Pubmed ID | 31579420 |
| Year | 2019 |
| Title | Long Non-Coding RNA Urothelial Cancer Associated 1 Can Regulate the Migration and Invasion of Colorectal Cancer Cells (SW480) via Myocardin-Related Transcription factor-A |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |