Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot |
| Sample | hepatocellular carcinoma tissues,blood, cell lines (HepG2, Huh7 ) |
| Expression Pattern | up-regulated |
| Function Description | TGF-?1, UCA1, and HXK2 expression levels were upregulated in tumor tissues comparing with adjacent healthy tissues. Patients that have high serum levels of TGF-?1, UCA1, and HXK2 showed lower overall survival rate compared with patients with low serum levels of TGF-?1, UCA1, and HXK2. TGF-?1, UCA1, and HXK2 overexpression promoted proliferation of hepatocellular carcinoma cell. |
| Pubmed ID | 30070319 |
| Year | 2018 |
| Title | TGF-?1 Upregulates the Expression of lncRNA UCA1 and Its Downstream HXK2 to Promote the Growth of Hepatocellular Carcinoma. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |