Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, other |
| Sample | NCI-H23 cell line (HCC827,HCC2935, SK-LU-1, NCI-H23, NCI-H1563,NCI-H1651) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that suppression of lncRNA UCA1 significantly reduced the viability of NCI-H23 cancer cells via induction of the apoptosis. Furthermore, the lncRNA UCA1 suppression significantly inhibited the migration and invasion of the NCI-H23 lung cancer at least in part via inhibition of mitogen-activated protein kinase 1 (MAPK1). Additionally, the suppression of MAPK1 exhibited similar effects on the proliferation, migration, and invasion of the NCI-H23 cells as that of UCA1 silencing. Finally, the co-suppression of lncRNA UCA1 and MAPK1 exhibited synergistic effects on cell proliferation, migration, and invasion. |
| Pubmed ID | 30468471 |
| Year | 2018 |
| Title | Suppression of Long Non-Coding RNA UCA1 Inhibits Proliferation and Invasion and Induces Apoptosis in Human Lung Cancer Cells |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |