Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | thyroid cancer tissues and cell lines (MTC, FTC-133,TPC-1, B-CPAP, SW579, and PDTC cells) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 was overexpressed in PTC tissues and thyroid cancer cells. UCA1 expression was positively correlated to tumor size, tumor stage, and metastasis of PTC. Overexpressed UCA1 promoted proliferation and invasion, whereas inhibited apoptosis of thyroid cancer cells via Wnt pathway. |
| Pubmed ID | 30229831 |
| Year | 2018 |
| Title | UCA1 Promotes Papillary Thyroid Carcinoma Development by Stimulating Cell Proliferation via Wnt Pathway |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |