Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi |
| Sample | Cell lines (H520, SKMES1) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 down-regulation inhibited cell proliferation and migration in both SKMES-1 and H520 lung cancer cells.Then we demonstrated that repressed UCA1 promoted the miR-193a expression and miR-193a could bind to the predicted binding site of UCA1.We then dissected the role of miR-193a in lung cancer and proved the anti-tumor role of miR-193a.Furthermore,miR-193a displayed its role in lung cancer via modulating the HMGB1 expression.In addition,over-expression of HMGB1 could restore the UCA1 knockdown induced repression of cell proliferation and migration. |
| Pubmed ID | 29355524 |
| Year | 2018 |
| Title | Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |