Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, RIP etc. |
| Sample | cancer tissues, cell cells (BxPC-3, SW1990, PaTu8988, and PANC-1) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 promoted cell migration and invasion of pancreatic cancer cells.Importantly, we found that UCA1 overexpression inhibited YAP phosphorylation, and increased YAP expression.Mechanistically,UCA1 interacted with MOB1,Lats1,and YAP, forming shielding composites. Moreover,we demonstrated that UCA1 increased YAP nuclear localization and stabilization, and improved TEAD luciferase activity. The present study provides insights into the mechanistic regulation of UCA1 promoting pancreatic cancer progression through the Hippo signaling pathway.It remains to be investigated whether UCA1 can act as a ceRNA by competitively binding correlative miRNA to maintain stable expression of YAP in PC cells. |
| Pubmed ID | 29510195 |
| Year | 2018 |
| Title | LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |