Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RNAi, Northern blot, Luciferase reporter assay, Flow cytometry assay etc. |
| Sample | pancreatic cancer tissues, cell lines (SW1990, BxPC-3, MiaPaCa-2, PANC-1, CAPAN-1) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 was overexpressed in PC tissues and cell lines. The proliferation of PC cells was inhibited after UCA1 was suppressed by a lentiviral vector. Cell apoptosis rate was largely promoted by down-regulating UCA1. Luciferase activity assay further comfirmed the targeting relationship between UCA1 and miR-135a. Moreover, miRNA-135a reversed the effect of UCA1 on cell apoptosis rate and cell viability in SW1990 cells. The migration and invasion capacity of PC cells suppressed by UCA1 siRNA was then enhanced by miR-135a inhibitor. |
| Pubmed ID | 28315290 |
| Year | 2017 |
| Title | UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer By Sponging MiR-135a. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |