Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR etc. |
| Sample | urine, cell line (T24) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 expression was found in T24 cell line and also found to be significantly higher in the cancer group as compared to the controls. UCA1 messenger RNA (mRNA) expression showed a significant association with stage and grade. UCA1 showed a sensitivity of 79.49% and a specificity of 79.73%, whereas urine cytology had a sensitivity of 66.67% and a specificity of 95.95% for TCC cases. Higher expression of UCA1 was associated with high grade (G2-G3, sensitivity=84.09%). |
| Pubmed ID | 25123267 |
| Year | 2014 |
| Title | Appraisal of diagnostic ability of UCA1 as a biomarker of carcinoma of the urinary bladder. |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |