Basic Information
| LncRNA/CircRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 |
| Ensemble | ENSG00000214049 |
| Refseq | NR_015379 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | PTX | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, western blot etc. |
| Sample | cell lines (SKOV3 and HeyA-8) |
| Expression Pattern | up-regulated |
| Function Description | Collectively, our study elaborated a novel UCA1/miR-129/ABCB1 regulatory axis underlying PTX resistance of OC cells, providing a potential therapeutic target for OC. |
| Pubmed ID | 29777711 |
| Year | 2018 |
| Title | UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis |
External Links
| Links for UCA1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |