Basic Information
| LncRNA/CircRNA Name | LINC-UFC1 |
| Synonyms | UFC1, HSPC155 |
| Region | GRCh38_1:161152776-161158856 |
| Ensemble | ENSG00000143222 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | cervical cancer tissues, cell lines (Hela and Siha) |
| Expression Pattern | up-regulated |
| Function Description | linc-UFC1 expression was significantly increased in cervical cancer tissues, and its overexpression was associated with the poor survival of patients with cervical cancer. Loss-of-function assays indicated that linc-UFC1 exerted as an oncogene because it promoted the growth and metastasis of cervical cancer cells in vitro and in vivo. Mechanistic investigations revealed that linc-UFC1 upregulated FOXP3 expression through competitively binding miR-34a. Finally, luciferase reporter and chromatin immunoprecipitation (ChIP) assays provided evidence that E2F1 could directly bind to the linc-UFC1 promoter region and enhance its transcription. |
| Pubmed ID | 29790665 |
| Year | 2018 |
| Title | Long Noncoding RNA UFC1 Is Activated by E2F1 and Exerts Oncogenic Properties by Functioning as a ceRNA of FOXP3 |
External Links
| Links for LINC-UFC1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |