Basic Information
| LncRNA/CircRNA Name | LINC-UFC1 |
| Synonyms | UFC1, HSPC155 |
| Region | GRCh38_1:161152776-161158856 |
| Ensemble | ENSG00000143222 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | NSCLC tumor tissues, cell lines (A549 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | UFC1 expression was upregulated in tumor tissues, serum, and serum exosomes of NSCLC patients and high level of UFC1 was associated with tumor infiltration.Exosome-transmitted UFC1 promotes NSCLC progression by inhibiting PTEN expression via EZH2-mediated epigenetic silencing. |
| Pubmed ID | 32242003 |
| Year | 2020 |
| Title | Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression |
External Links
| Links for LINC-UFC1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |