Basic Information
| LncRNA/CircRNA Name | UPAT |
| Synonyms | AOC4P, AOC4, UPAT |
| Region | GRCh38_17:42865922-42874369 |
| Ensemble | ENSG00000260105 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | NSCLC tissues, cell lines (H1299, H1650, H358 and A549) |
| Expression Pattern | up-regulated |
| Function Description | The present study demonstrated that lncRNA UPAT expression was upregulated in NSCLC tissues and significantly associated with tumor size and Tumor-Node-Metastasis stage. Additionally, UPAT promoted NSCLC cell proliferation and G1-S phase transition in vitro. Furthermore, UPAT promoted NSCLC cell proliferation, partly via increasing UHRF1 expression and consequently epigenetically silencing RASSF1 and CDH13 transcription. In addition, the knockdown of UHRF1 partially decreased the promotion of cell growth and G1-S phase transition caused by UPAT overexpression. |
| Pubmed ID | 30008828 |
| Year | 2018 |
| Title | Long Noncoding RNA UPAT Promoted Cell Proliferation via Increasing UHRF1 Expression in Non-Small Cell Lung Cancer |
External Links
| Links for UPAT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |