Basic Information
| LncRNA/CircRNA Name | VIM-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:17214239-17229985 |
| Ensemble | ENSG00000229124 |
| Refseq | NR_108061 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (SW1116, SW480, HT29, SW48), colorectal cancer tissue |
| Expression Pattern | up-regulated |
| Function Description | VIM-AS1 transcript was significantly upregulated in high-grade, lymph node metastasis and vascular invasion tumors.The downregulation of VIM-AS1 could inhibit tumor cell proliferation by inducing apoptosis, cellular senescence and arresting the cell cycle.VIM-AS1 might play a crucial role in cell migration as well as the epithelial to mesenchymal transition (EMT) of CRC cells. VIM-AS1 promotes tumor growth and metastasis by inducing EMT in CRC cells and could be considered as a novel tumor marker with probable value in diagnosis and CRC treatment. |
| Pubmed ID | 29656793 |
| Year | 2018 |
| Title | Long noncoding RNA VIM-AS1 promotes colorectal cancer progression and metastasis by inducing EMT. |
External Links
| Links for VIM-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |