Basic Information
| LncRNA/CircRNA Name | WFDC21P |
| Synonyms | WAP four-disulfide core domain 21 pseudogene |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | other |
| Sample | HepG2,Huh7 and PLC cells,liver cancer and adjacent liver tissue |
| Expression Pattern | down-regulated |
| Function Description | WFDC21P suppresses HCC cell proliferation and tumor growth.WFDC21P inhibits HCC cell metastasis.WFDC21P is a downstream target of Nur77, and functions as a tumor suppressor in HCC.WFDC21P interacts with two rate-limiting enzymes in glycolysis, thereby inhibiting glycolysis.WFDC21P could reverse the Warburg effect in HCC by modulating the activity of PFKP and PKM2. |
| Pubmed ID | 31959898 |
| Year | 2020 |
| Title | Nur77-activated lncRNA WFDC21P Attenuates Hepatocarcinogenesis via Modulating Glycolysis |
External Links
| Links for WFDC21P | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |