Basic Information
| LncRNA/CircRNA Name | WT1-AS |
| Synonyms | NA |
| Region | GRCh38_11:32435518-32458769 |
| Ensemble | ENSG00000183242 |
| Refseq | NR_023920 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical squamous cell carcinoma |
| ICD-0-3 | C53 |
| Methods | RT-qPCR, Western-blot |
| Sample | CSCC tissues,HPV positive human CSCC cell line, and C-33A, an HPV negative human CSCC cell line |
| Expression Pattern | down-regulated |
| Function Description | WT1-AS was down-regulated in CSCC tissues compared with non-cancer tissues.Analysis of the survival of CSCC patients revealed that low levels of WT1-AS were accompanied by poor survival. Significantly up-regulated p53 was observed after WT1-AS over-expression in CSCC cells, while p53 over-expression failed to affect WT1-AS. P53 and WT1-AS over-expression resulted in the inhibited proliferation of CSCC cells. |
| Pubmed ID | 31694597 |
| Year | 2019 |
| Title | LncRNA WT1-AS Up-Regulates p53 to Inhibit the Proliferation of Cervical Squamous Carcinoma Cells |
External Links
| Links for WT1-AS | GenBank HGNC NONCODE |
| Links for cervical squamous cell carcinoma | OMIM COSMIC |