Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Cell transfection, Western blot, Flow cytometry assay, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | bladder cancer tissues, cell lines (T24, 5637, SW780, J82 and UMUC3) |
| Expression Pattern | down-regulated |
| Function Description | CASC2 was significantly down-regulated in bladder cancer tissues and cell lines. Moreover, overexpression of lncRNA CASC2 remarkably reduced the cell growth, migration and invasion, as well as promoted early apoptosis of bladder cancer cell in vitro. Furthermore, we illustrated that lncRNA CASC2 inhibited Wnt/B-catenin signal pathway activity by decrasing the B-catenin expression and reversing the downstream target gene expression of Wnt signaling pathway. |
| Pubmed ID | 28199978 |
| Year | 2017 |
| Title | Down-regulation of lncRNA CASC2 promotes cell proliferation and metastasis of bladder cancer by activation of the Wnt/B-catenin signaling pathway. |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |