Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | glioma tumor tissues and normal health tissues. cell lines(U251 and A172) |
| Expression Pattern | up-regulated |
| Function Description | XIST and CREB1 were overexpressed whereas miR-329-3p was low-expressed in glioma tumors and cells compared with the normal counterparts. XIST knockdown inhibited cell proliferation, invasion and induced cell apoptosis by enhancing cell sensitivity to X-ray radiation in glioma. |
| Pubmed ID | 32271437 |
| Year | 2020 |
| Title | Overexpression of XIST Facilitates Cell Proliferation, Invasion and Suppresses Cell Apoptosis by Reducing Radio-Sensitivity of Glioma Cells via miR-329-3p/CREB1 Axis |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |