Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, luciferase reporter assay etc |
| Sample | NPC tissues,cell lines (HK-1 and C666-1) |
| Expression Pattern | up-regulated |
| Function Description | XIST and NEK5 were highly expressed while miR-381-3p was lowly expressed in NPC (tissues and cells) and hypoxia-induced NPC cells. Deficiency of XIST or NEK5 suppressed hypoxia-induced glycolysis and metastasis in NPC cells. Moreover, miR-381-3p could directly bind to XIST and its inhibition reversed the inhibitory effects of XIST knockdown on glycolysis and metastasis under hypoxia. |
| Pubmed ID | 32196601 |
| Year | 2020 |
| Title | Knockdown of lncRNA XIST Inhibits Hypoxia-Induced Glycolysis, Migration and Invasion Through Regulating miR-381-3p/NEK5 Axis in Nasopharyngeal Carcinoma |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |