Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Dual luciferase reporter assay, RIP, Western blot analysis, |
| Sample | LAD tissues,cells (A549, H1299, BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | Downregulation of XIST impeded proliferation, migration and invasion, and expedited apoptosis of LAD cells in vitro.Silencing of MDM2 blocked proliferation, migration and invasion, and boosted apoptosis of LAD cells in vitro. |
| Pubmed ID | 31968395 |
| Year | 2020 |
| Title | Long non-coding RNA XIST expedites lung adenocarcinoma progression through upregulating MDM2 expression via binding to miR-363-3p |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |