Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Luciferase assay |
| Sample | Patients and tissues specimens,OS cell lines MG-63, HOS, U2-OS and Saos-2, and the human normal cell line hFOB1.19 |
| Expression Pattern | up-regulated |
| Function Description | XIST expression was up-regulated but miR-375-3p was down-regulated in OS tissues and cells. Luciferase assay results demonstrated that miR-375-3p was a target of XIST and mTOR was a target mRNA of miR-375-3p. In addition, knockdown of XIST and mTOR inhibited OS cell proliferation and autophagy, but induced apoptosis. Knockdown of XIST could reverse the effect of miR-375-3p inhibitor on OS cells. |
| Pubmed ID | 31933968 |
| Year | 2019 |
| Title | Knockdown of lncRNA XIST Suppresses Osteosarcoma Progression by Inactivating AKT/mTOR Signaling Pathway by Sponging miR-375-3p |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |