Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | X inactive-specific transcript |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | RT-PCR, luciferase reporter assays, Western blot analysis |
| Sample | LSCC tissue,LSCC cell line TU212 |
| Expression Pattern | up-regulated |
| Function Description | the level of XIST was significantly higher in LSCC tissues that were associated with advanced Tumor-Node-Metastasis (TNM) stage and the presence of lymph node metastasis. Furthermore, the ability of human LSCC TU212 cells to proliferate, form colonies, migrate and invade was significantly suppressed, while cell apoptosis was significantly increased following knockdown of XIST. Further investigation revealed that XIST knockdown increased the expression of microRNA-144 (miR-144) by acting as an endogenous sponge of miR-144. |
| Pubmed ID | 31894287 |
| Year | 2020 |
| Title | lncRNA XIST Promotes the Progression of Laryngeal Squamous Cell Carcinoma by Sponging miR-144 to Regulate IRS1 Expression |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |