Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | CD4+, CD8+, T-cells, CD11b+F4/80+ macrophages, CD11b+Ly6C+, CD11b+Ly6G+ MDSCs immune cells | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | conservation | Recurrence |
Cancer&Entry Information
| Cancer Name | Colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | Colorectal tissues, Human colorectal adenocarcinoma cell lines SW620 and HCT116 |
| Expression Pattern | up-regulated |
| Function Description | CXCL12/CXCR4-induced upregulation of lncRNA XIST functioned as a ceRNA to sponge miR-133a-3p, thereby liberating the repression of RhoA by miR-133a-3p. The negative correlation of miR-133a-3p with RhoA was also confirmed in human CRC tissues and CXCR4+/??mice.lncRNAs XIST were predicted to bind to miR-133a-3p with high conservation. |
| Pubmed ID | 30678736 |
| Year | 2019 |
| Title | CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for Colorectal cancer | OMIM COSMIC |