Detail

Basic Information

LncRNA/CircRNA Name	XIST
Synonyms	NA
Region	GRCh38_X:73820651-73852753
Ensemble	ENSG00000229807
Refseq	NR_001564

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP
Sample	Human NSCLC cell lines H522 and Calu3, an bronchial epithelial cell line 16HBE, NSCLC tissue, adjacent normal tissue
Expression Pattern	up-regulated
Function Description	Expression levels of XIST and CBLL1 were markedly upregulated, while the miR-212-3p level was markedly downregulated in NSCLC tissues and cells. MiR-212-3p was identified as a direct target of XIST, and miR-212-3p was predicted to target CBLL1. XIST knockdown repressed NSCLC cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro, and suppressed tumor growth in vivo, while miR212-3p inhibition restored the effects. Furthermore, CBLL1 overexpression could abolish the effects of miR-212-3p overexpression on NSCLC cell proliferation, migration, invasion and EMT in vitro.
Pubmed ID	31646569
Year	2019
Title	Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/ CBLL1 axis in non small cell lung cancer cells

External Links

Links for XIST	GenBank HGNC NONCODE
Links for non small cell lung cancer	OMIM COSMIC