Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | testicular cancer |
| ICD-0-3 | C62 |
| Methods | qPCR etc. |
| Sample | testicular germ-cell tumour tissues |
| Expression Pattern | differential expression |
| Function Description | We developed a DNA tumour marker for TGCTs based on the unmethylated DNA profile of a neoplasm. The 5' end of the XIST gene is mainly hypomethylated in TGCTs irrespective of XIST expression. Male somatic cells, however, show complete methylation through the CpG sites, including the minimum promoter and XIST-conserved repeats. Identification of a XIST unmethylated fragment in male plasma might be diagnostic for TGCTs. |
| Pubmed ID | 14723995 |
| Year | 2004 |
| Title | XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for testicular cancer | OMIM COSMIC |