Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RNAi, in vitro knockdown, Luciferase reporter assay etc. |
| Sample | cell lines (PANC-1, ASPC-1, MIA PaCa-2, HPAC, CFAPC-1, BxPC-3), PC tissues |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of XIST significantly promoted the proliferation,migration and invasion, and suppressed cell apoptosis of BxPC-3 cells; knockdown of XIST significantly inhibited the proliferation,migration and invasion,and accelerated cell apoptosis of PANC-1 cells. Subsequently, we found that microRNA-34a-5p (miR-34a-5p) was downregulated in PC tissues,and predicted a poor prognosis in PC patients. In addition, the results indicated that miR-34a-5p is a target gene of XIST and was significantly negatively correlated with XIST. More importantly, miR-34a-5p rescued the facilitation of malignant behavior mediated by XIST. These results indicated that XIST and miR-34a-5p may be potential effective therapeutic targets for PC. |
| Pubmed ID | 29393501 |
| Year | 2018 |
| Title | Long non-coding RNA XIST exerts oncogenic functions in pancreatic cancer via miR-34a-5p. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |