Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, RNA-FISH, DNA-FISH, Methylation assay etc. |
| Sample | breast cancer tissues, cell lines (MCF7, MDA MB 231, T47D and HCC1937) |
| Expression Pattern | up-regulated |
| Function Description | XIST RNA levels comparable to those of non-BLC and significantly higher than those detected in sporadic BLC. In this tumor cell line XIST shows a misbehaviour, because it is expressed by an active X chromosome and does not stably coat the XIST expressing X chromosome. |
| Pubmed ID | 19440381 |
| Year | 2009 |
| Title | Misbehaviour of XIST RNA in breast cancer cells. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |